Reassurance

LEGEND-HTN Sub analysis: Assertion of Renal Safety of HCTZ

Hydrochlorothiazide treatment is better in hypertensive patients with varying levels of renal problems compared to Chlorthalidone.

Hydrochlorothiazide edges over Chlorthalidone in elderly with renal problems

Chlorthalidone use was associated with a higher risk of hypokalemia incidence and eGFR decline as compared with hydrochlorothiazide use.

Reassurance

BP Control

CV Protection

Safety

Right Dose

Guideline recommendations

Kidney Protection

Reference

Hripcsak G, Suchard MA, Shea S, Chen R, You SC, Pratt N, Madigan D, Krumholz HM, Ryan PB, Schuemie MJ. Comparison of cardiovascular and safety outcomes of chlorthalidone vs hydrochlorothiazide to treat hypertension. JAMA internal medicine. 2020 Apr 1;180(4):542-51

Edwards C et al. Comparison of Clinical Outcomes and Safety Associated With Chlorthalidone vs Hydrochlorothiazide in Older Adults With Varying Levels of Kidney Function. JAMA Netw Open. 2021 Sep 1;4(9):e2123365. Erratum in: JAMA Netw Open. 2023 May 1;6(5):e2317603.

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