HCTZ can reduce systolic blood pressure by an average of 11 mmHg and diastolic blood pressure by 5 mmHg at higher doses (50 mg/day) compared to placebo.
Lower doses also show effectiveness, with reductions of approximately 4 mmHg for systolic and 2 mmHg for diastolic pressures at lower doses (6.25 mg to 12.5 mg)
Dose-Dependent Effects: Higher doses of HCTZ lead to greater reductions in both systolic and diastolic blood pressure. For example, doses ranging from 6.25 mg to 50 mg exhibit progressively larger decreases in blood pressure, reinforcing HCTZ's versatility in treatment protocols.
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